Feeling isolated in her new job as a particle accelerator operator, Cindy Joe finds comfort in her unconventional pet, and Patrick Honner starts to doubt his lifelong love of math when grad school becomes a lonely experience.

Writer Matthew Dicks is startled to learn that his dog is in surgery -- and that he agreed to it the night before, and climatologist Simon Donner misses the ride to his field site in Madagascar, and must find his way there on his own. 

Science communicator Anthony Morgan receives an invitation to be vacuum-sealed to the bottom of a helicopter -- for science, and as a medical student, Elorm Avakame befriends a patient who is dying from alcoholism.

Comedian Josh Gondelman is threatened with a lawsuit after he reviews a new sexual enhancement product, and neuroscientist Heather Berlin and rapper Baba Brinkman try to use science to figure out if they belong together.